Prediction and analysis of nucleosome exclusion regions in the human genome.

ABSTRACT:

Background

Nucleosomes are the basic structural units of eukaryotic chromatin, and they play a significant role in regulating gene expression. Specific DNA sequence patterns are known, from empirical and theoretical studies, to influence DNA bending and flexibility, and have been shown to exclude nucleosomes. A whole genome localization of these patterns, and their analysis, can add important insights on the gene regulation mechanisms that depend upon the structure of chromatin in and around a gene.

Results

A whole genome annotation for nucleosome exclusion regions (NXRegions) was carried out on the human genome. Nucleosome exclusion scores (NXScores) were calculated individually for each nucleotide, giving a measure of how likely a specific nucleotide and its immediate neig

SUBMITTER: Radwan A 

PROVIDER: S-EPMC2386137 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature