Case-control cohort study of patients' perceptions of disability in mastocytosis.

ABSTRACT:

Background

Indolent forms of mastocytosis account for more than 90% of all cases, but the types and type and severity of symptoms and their impact on the quality of life have not been well studied. We therefore performed a case-control cohort study to examine self-reported disability and impact of symptoms on the quality of life in patients with mastocytosis.

Methodology/principal findings

In 2004, 363 mastocytosis patients and 90 controls in France were asked to rate to their overall disability (OPA score) and the severity of 38 individual symptoms. The latter was used to calculate a composite score (AFIRMM score). Of the 363 respondents, 262 were part of an ongoing pathophysiological study so that the following data were available: World Health Organization classification,

SUBMITTER: Hermine O 

PROVIDER: S-EPMC2386235 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature