Osteoprotegerin Lys3Asn polymorphism and the risk of fracture in older women.

ABSTRACT:

Context

Osteoprotegerin (OPG) is a soluble decoy receptor for receptor activator nuclear factor kappa-beta that blocks osteoclastic bone resorption.

Objective

We investigated the association between a Lys3Asn polymorphism in the OPG gene and bone mineral density (BMD), and the risk of fracture in 6695 women aged 65 yr and older participating in the Study of Osteoporotic Fractures.

Design

BMD was measured using either single-photon absorptiometry (Osteon Osteoanalyzer; Dove Medical Group, Los Angeles, CA) or dual-energy x-ray absorptiometry (Hologic QDR 1000; Hologic, Inc., Bedford, MA). Incident fractures were confirmed by physician adjudication of radiology reports. Genotyping was performed using an immobilized probe-based assay.

Results

Women who were homozyg

SUBMITTER: Moffett SP 

PROVIDER: S-EPMC2386283 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature