Roots of angiosperm formins: the evolutionary history of plant FH2 domain-containing proteins.

ABSTRACT:

Background

Shuffling of modular protein domains is an important source of evolutionary innovation. Formins are a family of actin-organizing proteins that share a conserved FH2 domain but their overall domain architecture differs dramatically between opisthokonts (metazoans and fungi) and plants. We performed a phylogenomic analysis of formins in most eukaryotic kingdoms, aiming to reconstruct an evolutionary scenario that may have produced the current diversity of domain combinations with focus on the origin of the angiosperm formin architectures.

Results

The Rho GTPase-binding domain (GBD/FH3) reported from opisthokont and Dictyostelium formins was found in all lineages except plants, suggesting its ancestral character. Instead, mosses and vascular plants possess the two fo

SUBMITTER: Grunt M 

PROVIDER: S-EPMC2386819 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature