Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat.

ABSTRACT:

Background

The Adhesion G protein-coupled receptors (GPCRs) are membrane-bound receptors with long N termini. This family has 33 members in humans. Several Adhesion GPCRs are known to have important physiological functions in CNS development and immune system response mediated by large cell surface ligands. However, the majority of Adhesion GPCRs are still poorly studied orphans with unknown functions.

Results

In this study we performed the extensive tissue localization analysis of the entire Adhesion GPCR family in rat and mouse. By applying the quantitative real-time PCR technique we have produced comparable expression profile for each of the members in the Adhesion family. The results are compared with literature data and data from the Allen Brain Atlas project. Our resul

SUBMITTER: Haitina T 

PROVIDER: S-EPMC2386866 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature