Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation.

ABSTRACT:

Background

The HOXA10 homeobox gene controls embryonic uterine development and adult endometrial receptivity. The three-amino-acid loop extension (TALE) family homeobox genes like myeloid ecotropic viral integration site 1 (MEIS) provide enhanced target gene activation and specificity in HOX-regulated cellular processes by acting as HOX cofactors.

Methods and results

Analysis of an Affymetrix data set in the public domain showed high expression of MEIS1 in human endometrium. MEIS1 expression was confirmed during the human menstrual cycle by RT-PCR and in situ hybridization and was increased during the secretory compared with proliferative phase of the cycle (P = 0.0001), the time of implantation. To assess the importance of maternal Meis1 expression in a mouse model, the ute

SUBMITTER: Xu B 

PROVIDER: S-EPMC2387222 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature