Dataset Information
Non-adherence to antipsychotic medication, relapse and rehospitalisation in recent-onset schizophrenia.
Ontology highlight
ABSTRACT: Background
The aims of this study were to describe outcome with respect to persistent psychotic symptoms, relapse of positive symptoms, hospital admissions, and application of treatment by coercion among patients with recent onset schizophrenia being adherent and non-adherent to anti-psychotic medication.Materials and methods
The study included 50 patients with recent onset schizophrenia, schizoaffective or schizophreniform disorders. The patients were clinically stable at study entry and had less than 2 years duration of psychotic symptoms. Good adherence to antipsychotic medication was defined as less than one month without medication. Outcomes for poor and good adherence were compared over a 24-month follow-up period.Results
The Odds Ratio (OR) of having a psychotic relapse was 10.27 and the OR of being admitted to hospital was 4.00 among non-adherent patients. Use of depot-antipsychotics were associated with relapses (OR = 6.44).Conclusion
Non-adherence was associated with relapse, hospital admission and having persistent psychotic symptoms. Interventions to increase adherence are needed.Trial registration
Current Controlled Trials NCT00184509. Key words: Adherence, schizophrenia, antipsychotic medication, admittances, relapse.
SUBMITTER: Morken G
PROVIDER: S-EPMC2390550 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Publications
Non-adherence to antipsychotic medication, relapse and rehospitalisation in recent-onset schizophrenia.
BMC psychiatry 20080430
<h4>Background</h4>The aims of this study were to describe outcome with respect to persistent psychotic symptoms, relapse of positive symptoms, hospital admissions, and application of treatment by coercion among patients with recent onset schizophrenia being adherent and non-adherent to anti-psychotic medication.<h4>Materials and methods</h4>The study included 50 patients with recent onset schizophrenia, schizoaffective or schizophreniform disorders. The patients were clinically stable at study ...[more]