Ontology highlight
ABSTRACT:
SUBMITTER: Ding F
PROVIDER: S-EPMC2390798 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Ding Feng F Sharma Shantanu S Chalasani Poornima P Demidov Vadim V VV Broude Natalia E NE Dokholyan Nikolay V NV
RNA (New York, N.Y.) 20080502 6
RNA molecules with novel functions have revived interest in the accurate prediction of RNA three-dimensional (3D) structure and folding dynamics. However, existing methods are inefficient in automated 3D structure prediction. Here, we report a robust computational approach for rapid folding of RNA molecules. We develop a simplified RNA model for discrete molecular dynamics (DMD) simulations, incorporating base-pairing and base-stacking interactions. We demonstrate correct folding of 150 structur ...[more]