Four Classes of Structurally Unusual Peptides from Two Marine-Derived Fungi: Structures and Bioactivities.

ABSTRACT: The structures and biological properties of peptides produced by two genera of marine-derived fungi, an atypical Acremonium sp., and a Metarrhizium sp. were explored. The Acremonium strain was isolated from a marine sponge and has previously been shown by our group to produce peptides from the efrapeptin and RHM families. The isolation and structure elucidation of the new linear pentadecapeptides efrapeptins Eα (1), H (2) and N-methylated octapeptides RHM3 (3) and RHM4 (4) were carried out through a combination of 1D and 2D NMR techniques and tandem MS. Additional known efrapeptins E, F, G and the known syctalidamides A and B were also isolated. The absolute configurations of 1 - 4 are proposed to be the same as the original compound families. The marine-sponge derived Metarrhizium sp. was

SUBMITTER: Boot CM 

PROVIDER: S-EPMC2390835 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature