The estrogen hypothesis of schizophrenia implicates glucose metabolism: association study in three independent samples.

ABSTRACT:

Background

Schizophrenia is a highly heritable complex psychiatric disorder with an underlying pathophysiology that is still not well understood. Metaanalyses of schizophrenia linkage studies indicate numerous but rather large disease-associated genomic regions, whereas accumulating gene- and protein expression studies have indicated an equally large set of candidate genes that only partially overlap linkage genes. A thorough assessment, beyond the resolution of current GWA studies, of the disease risk conferred by the numerous schizophrenia candidate genes is a daunting and presently not feasible task. We undertook these challenges by using an established clinical paradigm, the estrogen hypothesis of schizophrenia, as the criterion to select candidates among the numerous genes exp

SUBMITTER: Olsen L 

PROVIDER: S-EPMC2391158 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature