The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration.

ABSTRACT:

Background

Although the statement that age is the greatest risk factor for Age-related macular degeneration (AMD) is widely accepted, the cellular and molecular explanations for that clinical statement are not generally known. A major focus of AMD research is the retinal pigment epithelium (RPE)/choroid. The purpose of this study was to characterize the changes in the RPE/choroid with age that may provide a background for the development of AMD.

Methodology/principal findings

We compared the transcriptional profiles, key protein levels and histology of the RPE/choroid from young and old mice. Using three statistical methods, microarray data demonstrated marked changes in the old mouse. There were 315 genes differentially expressed with age; most of these genes were related t

SUBMITTER: Chen H 

PROVIDER: S-EPMC2394659 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature