Mixture modeling of transcript abundance classes in natural populations.

ABSTRACT:

Background

Populations diverge in genotype and phenotype under the influence of such evolutionary processes as genetic drift, mutation accumulation, and natural selection. Because genotype maps onto phenotype by way of transcription, it is of interest to evaluate how these evolutionary factors influence the structure of variation at the level of transcription. Here, we explore the distributions of cis-acting and trans-acting factors and their relative contributions to expression of transcripts that exhibit two or more classes of abundance among individuals within populations.

Results

Expression profiling using cDNA microarrays was conducted in Drosophila melanogaster adult female heads for 58 nearly isogenic lines from a North Carolina population and 50 from a California pop

SUBMITTER: Hsieh WP 

PROVIDER: S-EPMC2394757 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature