The Sas3p and Gcn5p histone acetyltransferases are recruited to similar genes.

ABSTRACT:

Background

Specific histone modifications can perform several cellular functions, for example, as signals to recruit trans-acting factors and as modulators of chromatin structure. Acetylation of Lys14 of histone H3 is the main target of many histone acetyltransferases in vitro and may play a central role in the stability of the nucleosome. This study is focused on the genome-wide binding of Saccharomyces cerevisiae histone acetyltransferases that are specific for Lys14 of histone H3.

Results

We have used a variation of the genome-wide location analysis method, based on a macroarray platform, to identify binding sites of yeast histone acetyltransferase catalytic subunits and to correlate their positions with acetylation of Lys14 of histone H3. Our results revealed that the hi

SUBMITTER: Rosaleny LE 

PROVIDER: S-EPMC2394765 | biostudies-literature | 2007

REPOSITORIES: biostudies-literature