Characterization of neutralizing antibody responses elicited by clade A envelope immunogens derived from early transmitted viruses.

ABSTRACT: The vast majority of studies with candidate immunogens based on the human immunodeficiency virus envelope (Env) have been conducted with Env proteins derived from clade B viruses isolated during chronic infection. Whether non-clade B Env protein immunogens will elicit antibodies with epitope specificities that are similar to those of antibodies elicited by clade B Envs and whether the antibodies elicited by Envs derived from early transmitted viruses will be similar to those elicited by Envs derived from viruses isolated during chronic infection are currently unknown. Here we performed immunizations with four clade A Envs, cloned directly from the peripheral blood of infected individuals during acute infection, which differed in lengths and extents of glycosylation. The antibody responses

SUBMITTER: Kraft Z 

PROVIDER: S-EPMC2395128 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature