Translational control plays a prominent role in the hepatocytic differentiation of HepaRG liver progenitor cells.

ABSTRACT:

Background

We investigated the molecular events associated with the differentiation of liver progenitor cells into functional and polarized hepatocytes, using human HepaRG cells that display potent hepatocytic differentiation-inducible properties and share some features with liver progenitor cells.

Results

Profiling of total and of polysome-bound transcripts isolated from HepaRG cells undergoing hepatocytic differentiation was performed. A group of 3,071 probe sets was reproducibly regulated by at least 2-fold in total or in polysome-bound RNA populations, upon differentiation. The fold changes in the total and the polysome-bound RNA populations for these 3,071 probe sets were poorly correlated (R = 0.38). Moreover, while the majority of the regulated polysome-bound RNA prob

SUBMITTER: Parent R 

PROVIDER: S-EPMC2395229 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature