Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity.

ABSTRACT:

Background

Investigations performed in mice and humans have acknowledged obesity as a low-grade inflammatory disease. Several molecular mechanisms have been convincingly shown to be involved in activating inflammatory processes and altering cell composition in white adipose tissue (WAT). However, the overall importance of these alterations, and their long-term impact on the metabolic functions of the WAT and on its morphology, remain unclear.

Results

Here, we analyzed the transcriptomic signature of the subcutaneous WAT in obese human subjects, in stable weight conditions and after weight loss following bariatric surgery. An original integrative functional genomics approach was applied to quantify relations between relevant structural and functional themes annotating differe

SUBMITTER: Henegar C 

PROVIDER: S-EPMC2395253 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature