Mechanisms of intron gain and loss in Cryptococcus.

ABSTRACT:

Background

Genome comparisons across deep phylogenetic divergences have revealed that spliceosomal intron gain and loss are common evolutionary events. However, because of the deep divergences involved in these comparisons, little is understood about how these changes occur, particularly in the case of intron gain. To ascertain mechanisms of intron gain and loss, we compared five relatively closely related genomes from the yeast Cryptococcus.

Results

We observe a predominance of intron loss over gain and identify a relatively slow intron loss rate in Cryptococcus. Some genes preferentially lose introns and a large proportion of intron losses occur in the middle of genes (so called internal intron loss). Finally, we identify a gene that displays a differential number of intro

SUBMITTER: Sharpton TJ 

PROVIDER: S-EPMC2395259 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature