A randomized, placebo-controlled trial of the bivalent killed, whole-cell, oral cholera vaccine in adults and children in a cholera endemic area in Kolkata, India.

ABSTRACT:

Objectives

An effective vaccine against cholera has been used for public health purposes in Vietnam since the 1990s. This vaccine was reformulated to meet WHO requirements. We assessed the safety and immunogenicity of the reformulated bivalent (Vibrio cholerae 01 and 0139) killed whole cell oral vaccine in a cholera endemic area in Kolkata, India.

Design

Double-blind, randomized, placebo controlled trial.

Setting

The trial was conducted in the clinical trial ward of the Infectious Diseases Hospital in Kolkata, India.

Participants

The participants were 101 healthy adults (males and non-pregnant females) aged 18-40 years and 100 healthy children (males and non-pregnant females) aged 1-17 years.

Interventions

Participants were randomized to receive either t

SUBMITTER: Mahalanabis D 

PROVIDER: S-EPMC2396289 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature