Bioinformatic analyses of mammalian 5'-UTR sequence properties of mRNAs predicts alternative translation initiation sites.

ABSTRACT:

Background

Utilization of alternative initiation sites for protein translation directed by non-AUG codons in mammalian mRNAs is observed with increasing frequency. Alternative initiation sites are utilized for the synthesis of important regulatory proteins that control distinct biological functions. It is, therefore, of high significance to define the parameters that allow accurate bioinformatic prediction of alternative translation initiation sites (aTIS). This study has investigated 5'-UTR regions of mRNAs to define consensus sequence properties and structural features that allow identification of alternative initiation sites for protein translation.

Results

Bioinformatic evaluation of 5'-UTR sequences of mammalian mRNAs was conducted for classification and identification

SUBMITTER: Wegrzyn JL 

PROVIDER: S-EPMC2396638 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature