The pairwise disconnectivity index as a new metric for the topological analysis of regulatory networks.

ABSTRACT:

Background

Currently, there is a gap between purely theoretical studies of the topology of large bioregulatory networks and the practical traditions and interests of experimentalists. While the theoretical approaches emphasize the global characterization of regulatory systems, the practical approaches focus on the role of distinct molecules and genes in regulation. To bridge the gap between these opposite approaches, one needs to combine 'general' with 'particular' properties and translate abstract topological features of large systems into testable functional characteristics of individual components. Here, we propose a new topological parameter--the pairwise disconnectivity index of a network's element - that is capable of such bridging.

Results

The pairwise disconnectivity

SUBMITTER: Potapov AP 

PROVIDER: S-EPMC2396639 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature