Characteristics of nucleosome core DNA and their applications in predicting nucleosome positions.

ABSTRACT: By analyzing dinucleotide position-frequency data of yeast nucleosome-bound DNA sequences, dinucleotide periodicities of core DNA sequences were investigated. Within frequency domains, weakly bound dinucleotides (AA, AT, and the combinations AA-TT-TA and AA-TT-TA-AT) present doublet peaks in a periodicity range of 10-11 bp, and strongly bound dinucleotides present a single peak. A time-frequency analysis, based on wavelet transformation, indicated that weakly bound dinucleotides of core DNA sequences were spaced smaller (approximately 10.3 bp) at the two ends, with larger (approximately 11.1 bp) spacing in the middle section. The finding was supported by DNA curvature and was prevalent in all core DNA sequences. Therefore, three approaches were developed to predict nucleosome positions. Af

SUBMITTER: Liu H 

PROVIDER: S-EPMC2397361 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature