Genomic and bioinformatics analysis of human adenovirus type 37: new insights into corneal tropism.

ABSTRACT:

Background

Human adenovirus type 37 (HAdV-37) is a major etiologic agent of epidemic keratoconjunctivitis, a common and severe eye infection associated with long-term visual morbidity due to persistent corneal inflammation. While HAdV-37 has been known for over 20 years as an important cause, the complete genome sequence of this serotype has yet to be reported. A detailed bioinformatics analysis of the genome sequence of HAdV-37 is extremely important to understanding its unique pathogenicity in the eye.

Results

We sequenced and annotated the complete genome of HAdV-37, and performed genomic and bioinformatics comparisons with other HAdVs to identify differences that might underlie the unique corneal tropism of HAdV-37. Global pairwise genome alignment with HAdV-9, a human s

SUBMITTER: Robinson CM 

PROVIDER: S-EPMC2397415 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature