Functional diversification of duplicate genes through subcellular adaptation of encoded proteins.

ABSTRACT:

Background

Gene duplication is the primary source of new genes with novel or altered functions. It is known that duplicates may obtain these new functional roles by evolving divergent expression patterns and/or protein functions after the duplication event. Here, using yeast (Saccharomyces cerevisiae) as a model organism, we investigate a previously little considered mode for the functional diversification of duplicate genes: subcellular adaptation of encoded proteins.

Results

We show that for 24-37% of duplicate gene pairs derived from the S. cerevisiae whole-genome duplication event, the two members of the pair encode proteins that localize to distinct subcellular compartments. The propensity of yeast duplicate genes to evolve new localization patterns depends to a large e

SUBMITTER: Marques AC 

PROVIDER: S-EPMC2397506 | biostudies-literature | 2008

REPOSITORIES: biostudies-literature