Modelling of the regulation of the hilA promoter of type three secretion system of Salmonella enterica serovar Typhimurium.

ABSTRACT: One of the most common modes of secretion of toxins in gram-negative bacteria is via the type three secretion system (TTSS), which enables the toxins to be specifically exported into the host cell. The hilA gene product is a key regulator of the expression of the TTSS located on the pathogenicity island (SPI-1) of Salmonella enterica serovar Typhimurium. It has been proposed earlier that the regulation of HilA expression is via a complex feedforward loop involving the transactivators HilD, HilC and RtsA. In this paper, we have constructed a mathematical model of regulation of hilA-promoter by all the three activators using two feedforward loops. We have modified the model to include additional complexities in regulation such as the proposed positive feedback and cross regulations of the th

SUBMITTER: Maithreye R 

PROVIDER: S-EPMC2398718 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature