Defining a modular signalling network from the fly interactome.

ABSTRACT:

Background

Signalling pathways relay information by transmitting signals from cell surface receptors to intracellular effectors that eventually activate the transcription of target genes. Since signalling pathways involve several types of molecular interactions including protein-protein interactions, we postulated that investigating their organization in the context of the global protein-protein interaction network could provide a new integrated view of signalling mechanisms.

Results

Using a graph-theory based method to analyse the fly protein-protein interaction network, we found that each signalling pathway is organized in two to three different signalling modules. These modules contain canonical proteins of the signalling pathways, known regulators as well as other protei

SUBMITTER: Baudot A 

PROVIDER: S-EPMC2405789 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature