Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males.

ABSTRACT: The level of dietary energy intake influences metabolism, reproductive function, the development of age-related diseases, and even cognitive behavior. Because males and females typically play different roles in the acquisition and allocation of energy resources, we reasoned that dietary energy intake might differentially affect the brains of males and females at the molecular level. To test this hypothesis, we performed a gene array analysis of the hippocampus in male and female rats that had been maintained for 6 months on either ad libitum (control), 20% caloric restriction (CR), 40% CR, intermittent fasting (IF) or high fat/high glucose (HFG) diets. These diets resulted in expected changes in body weight, and circulating levels of glucose, insulin and leptin. However, the CR diets signi

SUBMITTER: Martin B 

PROVIDER: S-EPMC2405949 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature