A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2.

ABSTRACT: Colorectal cancer is the second most leading cause of cancer death among adult Americans. Two autosomal dominant hereditary forms of the disease, familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer, together account for perhaps 5% of all cases. However, in approximately 20% of additional colon cancer cases, the affected individuals report a family history of colon cancer in a first-degree relative. Similar familial clusters of colon cancer and early-onset colon adenomas have also been reported. To determine whether such familial aggregations arise by chance or reflect a hereditary colon cancer susceptibility, we conducted a whole genome scan to test for genetic linkage in 53 kindreds in which two or more siblings were affected by age 65 or younger with colon cancer

SUBMITTER: Wiesner GL 

PROVIDER: S-EPMC240727 | biostudies-literature | 2003 Oct

REPOSITORIES: biostudies-literature