ORMDL3 gene is associated with asthma in three ethnically diverse populations.

ABSTRACT:

Rationale

Independent replication of genetic associations in complex diseases, particularly in whole-genome association studies, is critical to confirm the association.

Objectives

A whole-genome association study identified ORMDL3 as a promising candidate gene for asthma in white populations. Here, we attempted to confirm the role of ORMDL3 genetic variants in asthma in three ethnically diverse populations: Mexican, Puerto Rican, and African American.

Methods

We used family-based analyses to test for association between seven candidate single-nucleotide polymorphisms (SNPs) in and around the ORMDL3 gene and asthma and related phenotypes in 701 Puerto Rican and Mexican parent-child trios. We also evaluated these seven SNPs and an additional ORMDL3 SNP in 264 African Am

SUBMITTER: Galanter J 

PROVIDER: S-EPMC2408437 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature