Decreased endothelin receptor B expression in large primary uveal melanomas is associated with early clinical metastasis and short survival.

ABSTRACT: The most devastating aspect of cancer is the metastasis of tumour cells to organs distant from the original tumour site. The major problem facing oncologists treating uveal melanoma, the most common cancer of the eye, is metastatic disease. To lower mortality, it is necessary to increase our understanding of the molecular genetic alterations involved in this process. Using suppression subtractive hybridisation, we have analysed differential gene expression between four primary tumours from patients who have developed clinical metastasis and four primary tumours from patients with no evidence of metastasis to date. We have identified endothelin receptor type B as differentially expressed between these tumours and confirmed this observation using comparative multiplex RT-PCR. In a further 33

SUBMITTER: Smith SL 

PROVIDER: S-EPMC2408898 | biostudies-literature | 2002 Nov

REPOSITORIES: biostudies-literature