How to record a million synaptic weights in a hippocampal slice.

ABSTRACT: A key step toward understanding the function of a brain circuit is to find its wiring diagram. New methods for optical stimulation and optical recording of neurons make it possible to map circuit connectivity on a very large scale. However, single synapses produce small responses that are difficult to measure on a large scale. Here I analyze how single synaptic responses may be detectable using relatively coarse readouts such as optical recording of somatic calcium. I model a network consisting of 10,000 input axons and 100 CA1 pyramidal neurons, each represented using 19 compartments with voltage-gated channels and calcium dynamics. As single synaptic inputs cannot produce a measurable somatic calcium response, I stimulate many inputs as a baseline to elicit somatic action potentials lead

SUBMITTER: Bhalla US 

PROVIDER: S-EPMC2409153 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature