Genetically programmed differences in epidermal host defense between psoriasis and atopic dermatitis patients.

ABSTRACT: In the past decades, chronic inflammatory diseases such as psoriasis, atopic dermatitis, asthma, Crohn's disease and celiac disease were generally regarded as immune-mediated conditions involving activated T-cells and proinflammatory cytokines produced by these cells. This paradigm has recently been challenged by the finding that mutations and polymorphisms in epithelium-expressed genes involved in physical barrier function or innate immunity, are risk factors of these conditions. We used a functional genomics approach to analyze cultured keratinocytes from patients with psoriasis or atopic dermatitis and healthy controls. First passage primary cells derived from non-lesional skin were stimulated with pro-inflammatory cytokines, and expression of a panel of 55 genes associated with epiderm

SUBMITTER: Zeeuwen PL 

PROVIDER: S-EPMC2409155 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature