Comparative genome analysis of filamentous fungi reveals gene family expansions associated with fungal pathogenesis.

ABSTRACT: Fungi and oomycetes are the causal agents of many of the most serious diseases of plants. Here we report a detailed comparative analysis of the genome sequences of thirty-six species of fungi and oomycetes, including seven plant pathogenic species, that aims to explore the common genetic features associated with plant disease-causing species. The predicted translational products of each genome have been clustered into groups of potential orthologues using Markov Chain Clustering and the data integrated into the e-Fungi object-oriented data warehouse (http://www.e-fungi.org.uk/). Analysis of the species distribution of members of these clusters has identified proteins that are specific to filamentous fungal species and a group of proteins found only in plant pathogens. By comparing the gene

SUBMITTER: Soanes DM 

PROVIDER: S-EPMC2409186 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature