Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays.

ABSTRACT:

Background

The vast majority of human genes (>70%) are alternatively spliced. Although alternative pre-mRNA processing is modified in multiple tumors, alternative hyper-splicing signatures specific to particular tumor types are still lacking. Here, we report the use of Affymetrix Human Exon Arrays to spot hyper-splicing events characteristic of myasthenia gravis (MG)-thymoma, thymic tumors which develop in patients with MG and discriminate them from colon cancer changes.

Methodology/principal findings

We combined GO term to parent threshold-based and threshold-independent ad-hoc functional statistics with in-depth analysis of key modified transcripts to highlight various exon-specific changes. These denote alternative splicing in MG-thymoma tumors compared to healthy human t

SUBMITTER: Soreq L 

PROVIDER: S-EPMC2409220 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature