Mitochondria-dependent signalling pathway are involved in the early process of radiation-induced bystander effects.

ABSTRACT: Bystander effects induced by cytoplasmic irradiation have been reported recently. However, the mechanism(s) underlying, such as the functional role of mitochondria, is not clear. In the present study, we used either mtDNA-depleted (rho(0)) A(L) or normal (rho(+)) A(L) cells as irradiated donor cells and normal human skin fibroblasts as receptor cells in a series of medium transfer experiments to investigate the mitochondria-related signal process. Our results indicated that mtDNA-depleted cells or normal A(L) cells treated with mitochondrial respiratory chain function inhibitors had an attenuated gamma-H2AX induction, which indicates that mitochondria play a functional role in bystander effects. Moreover, it was found that treatment of normal A(L) donor cells with specific inhibitors of NO

SUBMITTER: Chen S 

PROVIDER: S-EPMC2410123 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature