Identification of novel vascular markers through gene expression profiling of tumor-derived endothelium.

ABSTRACT:

Background

Targeting tumor angiogenesis and vasculature is a promising strategy for the inhibition of tumor growth and dissemination. Evidence suggests that tumor vasculature expresses unique markers that distinguish it from normal vasculature. Our efforts focused on the molecular characterization of endothelial cells (EC) in the search for selective markers of tumor vasculature that might be helpful for the development of effective therapeutic approaches.

Results

We investigated by microarray analysis the gene expression profiles of EC purified and cultured from tumor (ovarian carcinoma [HOC-EC]) and normal (human adrenal gland [HA-EC]) tissue specimens. We found distinct transcriptional features characterizing the EC of different origin, and identified 158 transcripts high

SUBMITTER: Ghilardi C 

PROVIDER: S-EPMC2410137 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature