Structure and expression pattern of Oct4 gene are conserved in vole Microtus rossiaemeridionalis.

ABSTRACT:

Background

Oct4 is a POU-domain transcriptional factor which is essential for maintaining pluripotency in several mammalian species. The mouse, human, and bovine Oct4 orthologs display a high conservation of nucleotide sequence and genomic organization.

Results

Here we report an isolation of a common vole (Microtus rossiaemeridionalis) Oct4 ortholog. Organization and exon-intron structure of vole Oct4 gene are similar to the gene organization in other mammalian species. It consists of five exons and a regulatory region including the minimal promoter, proximal and distal enhancers. Promoter and regulatory regions of the vole Oct4 gene also display a high similarity to the corresponding regions of Oct4 in other mammalian species, and are active during the transient transfectio

SUBMITTER: Medvedev SP 

PROVIDER: S-EPMC2410140 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature