Identification of heterogeneity among soft tissue sarcomas by gene expression profiles from different tumors.

ABSTRACT: The heterogeneity that soft tissue sarcomas (STS) exhibit in their clinical behavior, even within histological subtypes, complicates patient care. Histological appearance is determined by gene expression. Morphologic features are generally good predictors of biologic behavior, however, metastatic propensity, tumor growth, and response to chemotherapy may be determined by gene expression patterns that do not correlate well with morphology. One approach to identify heterogeneity is to search for genetic markers that correlate with differences in tumor behavior. Alternatively, subsets may be identified based on gene expression patterns alone, independent of knowledge of clinical outcome. We have reported gene expression patterns that distinguish two subgroups of clear cell renal carcinoma (cc

SUBMITTER: Skubitz KM 

PROVIDER: S-EPMC2412854 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature