Rab proteins and Rab-associated proteins: major actors in the mechanism of protein-trafficking disorders.

ABSTRACT:

Unlabelled

Ras-associated binding (Rab) proteins and Rab-associated proteins are key regulators of vesicle transport, which is essential for the delivery of proteins to specific intracellular locations. More than 60 human Rab proteins have been identified, and their function has been shown to depend on their interaction with different Rab-associated proteins regulating Rab activation, post-translational modification and intracellular localization. The number of known inherited disorders of vesicle trafficking due to Rab cycle defects has increased substantially during the past decade. This review describes the important role played by Rab proteins in a number of rare monogenic diseases as well as common multifactorial human ones. Although the clinical phenotype in these monogenic i

SUBMITTER: Corbeel L 

PROVIDER: S-EPMC2413085 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature