Mining small RNA structure elements in untranslated regions of human and mouse mRNAs using structure-based alignment.

ABSTRACT:

Background

UnTranslated Regions (UTRs) of mRNAs contain regulatory elements for various aspects of mRNA metabolism, such as mRNA localization, translation, and mRNA stability. Several RNA stem-loop structures in UTRs have been experimentally identified, including the histone 3' UTR stem-loop structure (HSL3) and iron response element (IRE). These stem-loop structures are conserved among mammalian orthologs, and exist in a group of genes encoding proteins involved in the same biological pathways. It is not known to what extent RNA structures like these exist in all mammalian UTRs.

Results

In this paper we took a systematic approach, named GLEAN-UTR, to identify small stem-loop RNA structure elements in UTRs that are conserved between human and mouse orthologs and exist in mul

SUBMITTER: Khaladkar M 

PROVIDER: S-EPMC2413145 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature