Comparative analysis of full genomic sequences among different genotypes of dengue virus type 3.

ABSTRACT:

Background

Although the previous study demonstrated the envelope protein of dengue viruses is under purifying selection pressure, little is known about the genetic differences of full-length viral genomes of DENV-3. In our study, complete genomic sequencing of DENV-3 strains collected from different geographical locations and isolation years were determined and the sequence diversity as well as selection pressure sites in the DENV genome other than within the E gene were also analyzed.

Results

Using maximum likelihood and Bayesian approaches, our phylogenetic analysis revealed that the Taiwan's indigenous DENV-3 isolated from 1994 and 1998 dengue/DHF epidemics and one 1999 sporadic case were of the three different genotypes - I, II, and III, each associated with DENV-3 circu

SUBMITTER: King CC 

PROVIDER: S-EPMC2413216 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature