The Xenopus FcR family demonstrates continually high diversification of paired receptors in vertebrate evolution.

ABSTRACT:

Background

Recent studies have revealed an unexpected diversity of domain architecture among FcR-like receptors that presumably fulfill regulatory functions in the immune system. Different species of mammals, as well as chicken and catfish have been found to possess strikingly different sets of these receptors. To better understand the evolutionary history of paired receptors, we extended the study of FcR-like genes in amphibian representatives Xenopus tropicalis and Xenopus laevis.

Results

The diploid genome of X. tropicalis contains at least 75 genes encoding paired FcR-related receptors designated XFLs. The allotetraploid X. laevis displays many similar genes primarily expressed in lymphoid tissues. Up to 35 domain architectures generated by combinatorial joining of six I

SUBMITTER: Guselnikov SV 

PROVIDER: S-EPMC2413239 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature