On the role of the MAGUK proteins encoded by Drosophila varicose during embryonic and postembryonic development.

ABSTRACT:

Background

Membrane-associated guanylate kinases (MAGUKs) form a family of scaffolding proteins, which are often associated with cellular junctions, such as the vertebrate tight junction, the Drosophila septate junction or the neuromuscular junction. Their capacity to serve as platforms for organising larger protein assemblies results from the presence of several protein-protein interaction domains. They often appear in different variants suggesting that they also mediate dynamic changes in the composition of the complexes.

Results

Here we show by electron microscopic analysis that Drosophila embryos lacking varicose function fail to develop septate junctions in the tracheae and the epidermis. In the embryo and in imaginal discs varicose expresses two protein isoforms, which

SUBMITTER: Bachmann A 

PROVIDER: S-EPMC2414870 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature