Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile.

ABSTRACT:

Background

In high grade gliomas, 1p19q codeletion and EGFR amplification are mutually exclusive and predictive of dramatically different outcomes. We performed a microarray gene expression study of four high grade gliomas with 1p19q codeletion and nine with EGFR amplification, identified by CGH-array.

Results

The two groups of gliomas exhibited very different gene expression profiles and were consistently distinguished by unsupervised clustering analysis. One of the most striking differences was the expression of normal brain genes by oligodendrogliomas with 1p19q codeletion. These gliomas harbored a gene expression profile that partially resembled the gene expression of normal brain samples, whereas gliomas with EGFR amplification expressed many genes in common with gliobl

SUBMITTER: Ducray F 

PROVIDER: S-EPMC2415112 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature