Evolutionary persistence of the molybdopyranopterin-containing sulfite oxidase protein fold.

ABSTRACT:

Summary

The importance of molybdoenzymes is exemplified both by the debilitating and fatal human diseases caused by their deficiency and by their persistence throughout evolution. Here, we show that the protein fold of the molybdopyranopterin-containing domain of sulfite oxidase (the SUOX fold) can be found in all three domains of life. Analyses of sequence data and protein structure comparisons (secondary structure matching) show that the SUOX fold is found in enzymes that have quite distinct macromolecular architectures comprising one or more domains and sometimes subsidiary subunits. These are summarized as follows: (i) animal SUOXs that contain an N-terminal cytochrome b(5) domain and an SUOX fold fused to a C-terminal dimerization domain; (ii) plant SUOX that contains an SUOX

SUBMITTER: Workun GJ 

PROVIDER: S-EPMC2415749 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature