DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress.

ABSTRACT: DEK is a nuclear phosphoprotein implicated in oncogenesis and autoimmunity and a major component of metazoan chromatin. The intracellular cues that control the binding of DEK to DNA and its pleiotropic functions in DNA- and RNA-dependent processes have remained mainly elusive so far. Our recent finding that the phosphorylation status of DEK is altered during death receptor-mediated apoptosis suggested a potential involvement of DEK in stress signaling. In this study, we show that in cells committed to die, a portion of the cellular DEK pool is extensively posttranslationally modified by phosphorylation and poly(ADP-ribosyl)ation. Through interference with DEK expression, we further show that DEK promotes the repair of DNA lesions and protects cells from genotoxic agents that typically trig

SUBMITTER: Kappes F 

PROVIDER: S-EPMC2423161 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature