Comparison of pancreas juice proteins from cancer versus pancreatitis using quantitative proteomic analysis.

ABSTRACT:

Objectives

Pancreatitis is an inflammatory condition of the pancreas. However, it often shares many molecular features with pancreatic cancer. Biomarkers present in pancreatic cancer frequently occur in the setting of pancreatitis. The efforts to develop diagnostic biomarkers for pancreatic cancer have thus been complicated by the false-positive involvement of pancreatitis.

Methods

In an attempt to develop protein biomarkers for pancreatic cancer, we previously use quantitative proteomics to identify and quantify the proteins from pancreatic cancer juice. Pancreatic juice is a rich source of proteins that are shed by the pancreatic ductal cells. In this study, we used a similar approach to identify and quantify proteins from pancreatitis juice.

Results

In total, 72 pr

SUBMITTER: Chen R 

PROVIDER: S-EPMC2423229 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature