Density of common complex ocular traits in the aging eye: analysis of secondary traits in genome-wide association studies.

ABSTRACT: Genetic association studies are identifying genetic risks for common complex ocular traits such as age-related macular degeneration (AMD). The subjects used for discovery of these loci have been largely from clinic-based, case-control studies. Typically, only the primary phenotype (e.g., AMD) being studied is systematically documented and other complex traits (e.g., affecting the eye) are largely ignored. The purpose of this study was to characterize these other or secondary complex ocular traits present in the cases and controls of clinic-based studies being used for genetic study of AMD. The records of 100 consecutive new patients (of any diagnosis) age 60 or older for which all traits affecting the eye had been recorded systematically were reviewed. The average patient had 3.5 distinct

SUBMITTER: Edwards AO 

PROVIDER: S-EPMC2424139 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature