Large-scale computational and statistical analyses of high transcription potentialities in 32 prokaryotic genomes.

ABSTRACT: This article compares 32 bacterial genomes with respect to their high transcription potentialities. The sigma70 promoter has been widely studied for Escherichia coli model and a consensus is known. Since transcriptional regulations are known to compensate for promoter weakness (i.e. when the promoter similarity with regard to the consensus is rather low), predicting functional promoters is a hard task. Instead, the research work presented here comes within the scope of investigating potentially high ORF expression, in relation with three criteria: (i) high similarity to the sigma70 consensus (namely, the consensus variant appropriate for each genome), (ii) transcription strength reinforcement through a supplementary binding site--the upstream promoter (UP) element--and (iii) enhancement th

SUBMITTER: Sinoquet C 

PROVIDER: S-EPMC2425493 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature