Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary.

ABSTRACT:

Background

The aging of reproductive organs is not only a major social issue, but of special interest in aging research. A long-standing view of 'immortal germ line versus mortal soma' poses an important question of whether the reproductive tissues age in similar ways to the somatic tissues. As a first step to understand this phenomenon, we examine global changes in gene expression patterns by DNA microarrays in ovaries and testes of C57BL/6 mice at 1, 6, 16, and 24 months of age. In addition, we compared a group of mice on ad libitum (AL) feeding with a group on lifespan-extending 40% calorie restriction (CR).

Results

We found that gene expression changes occurred in aging gonads, but were generally different from those in somatic organs during aging. For example, only two

SUBMITTER: Sharov AA 

PROVIDER: S-EPMC2426674 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature