Generation of a non-small cell lung cancer transcriptome microarray.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. At present no reliable biomarkers are available to guide the management of this condition. Microarray technology may allow appropriate biomarkers to be identified but present platforms are lacking disease focus and are thus likely to miss potentially vital information contained in patient tissue samples.

Methods

A combination of large-scale in-house sequencing, gene expression profiling and public sequence and gene expression data mining were used to characterise the transcriptome of NSCLC and the data used to generate a disease-focused microarray - the Lung Cancer DSA research tool.

Results

Built on the Affymetrix GeneChip platform, the Lung Cancer DSA research tool allo

SUBMITTER: Tanney A 

PROVIDER: S-EPMC2426710 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature